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Chfr and RNF8 synergistically regulate ATM activation
Protein ubiquitination is a critical component of the DNA damage response. To study the mechanism of the DNA damage-induced ubiquitination pathway, we analyzed the impact of the loss of two E3 ubiquitin ligases, RNF8 and Chfr. Interestingly, DNA damage-induced ATM activation is suppressed in RNF8 an...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3130800/ https://ncbi.nlm.nih.gov/pubmed/21706008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2078 |
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