Recruited Cells Can Become Transformed and Overtake PDGF-Induced Murine Gliomas In Vivo during Tumor Progression

BACKGROUND: Gliomas are thought to form by clonal expansion from a single cell-of-origin, and progression-associated mutations to occur in its progeny cells. Glioma progression is associated with elevated growth factor signaling and loss of function of tumor suppressors Ink4a, Arf and Pten. Yet, gli...

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Autori principali: Fomchenko, Elena I., Dougherty, Joseph D., Helmy, Karim Y., Katz, Amanda M., Pietras, Alexander, Brennan, Cameron, Huse, Jason T., Milosevic, Ana, Holland, Eric C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130733/
https://ncbi.nlm.nih.gov/pubmed/21754979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020605
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