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Hedgehog activates Fused through phosphorylation to elicit a full spectrum of pathway responses
In flies and mammals extracellular Hedgehog (Hh) molecules alter cell fates and proliferation by regulating the levels and activities of Ci/Gli family transcription factors. How Hh-induced activation of transmembrane Smoothened (Smo) proteins reverses Ci/Gli inhibition by Suppressor of Fused (SuFu)...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3130625/ https://ncbi.nlm.nih.gov/pubmed/21664578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.04.020 |
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