An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling

The B-lymphocyte lineage is a leading system for analyzing gene regulatory networks (GRNs) that orchestrate distinct cell fate transitions. Upon antigen recognition, B cells can diversify their immunoglobulin (Ig) repertoire via somatic hypermutation (SHM) and/or class switch DNA recombination (CSR)...

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Hauptverfasser: Sciammas, Roger, Li, Ying, Warmflash, Aryeh, Song, Yiqiang, Dinner, Aaron R, Singh, Harinder
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130558/
https://ncbi.nlm.nih.gov/pubmed/21613984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.25
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