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Adaptation by stochastic switching of a monostable genetic circuit in Escherichia coli
Stochastic switching is considered as a cost-saving strategy for adaptation to environmental challenges. We show here that stochastic switching of a monostable circuit can mediate the adaptation of the engineered OSU12-hisC Escherichia coli strain to histidine starvation. In this strain, the hisC ge...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3130557/ https://ncbi.nlm.nih.gov/pubmed/21613982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.24 |
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