RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma

AIDS patients undergoing autologous transplantation for lymphoma were treated with gene-modified peripheral blood derived (CD34+) hematopoietic progenitor cells (HPC) expressing 3 RNA-based anti-HIV moieties (Tat/Rev shRNA, TAR decoy and CCR5 ribozyme). In vitro analysis of gene-modified HPC showed...

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Detalhes bibliográficos
Main Authors: DiGiusto, David L., Krishnan, Amrita, Li, Lijing, Li, Haitang, Li, Shirley, Rao, Anitha, Mi, Shu, Yam, Priscilla, Stinson, Sherri, Kalos, Michael, Alvarnas, Joseph, Lacey, Simon F., Yee, Jiing-Kuan, Li, Mingjie, Couture, Larry, Hsu, David, Forman, Stephen J., Rossi, John J., Zaia, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130552/
https://ncbi.nlm.nih.gov/pubmed/20555022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000931
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