G4 motifs correlate with promoter-proximal transcriptional pausing in human genes

The RNA Pol II transcription complex pauses just downstream of the promoter in a significant fraction of human genes. The local features of genomic structure that contribute to pausing have not been defined. Here, we show that genes that pause are more G-rich within the region flanking the transcrip...

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Autors principals: Eddy, Johanna, Vallur, Aarthy C., Varma, Sudir, Liu, Hongfang, Reinhold, William C., Pommier, Yves, Maizels, Nancy
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Gene Regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130262/
https://ncbi.nlm.nih.gov/pubmed/21371997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr079
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