GPHMM: an integrated hidden Markov model for identification of copy number alteration and loss of heterozygosity in complex tumor samples using whole genome SNP arrays

There is an increasing interest in using single nucleotide polymorphism (SNP) genotyping arrays for profiling chromosomal rearrangements in tumors, as they allow simultaneous detection of copy number and loss of heterozygosity with high resolution. Critical issues such as signal baseline shift due t...

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Detalles Bibliográficos
Main Authors: Li, Ao, Liu, Zongzhi, Lezon-Geyda, Kimberly, Sarkar, Sudipa, Lannin, Donald, Schulz, Vincent, Krop, Ian, Winer, Eric, Harris, Lyndsay, Tuck, David
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
Computational Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130254/
https://ncbi.nlm.nih.gov/pubmed/21398628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr014
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