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GPHMM: an integrated hidden Markov model for identification of copy number alteration and loss of heterozygosity in complex tumor samples using whole genome SNP arrays

There is an increasing interest in using single nucleotide polymorphism (SNP) genotyping arrays for profiling chromosomal rearrangements in tumors, as they allow simultaneous detection of copy number and loss of heterozygosity with high resolution. Critical issues such as signal baseline shift due t...

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Bibliografiske detaljer
Main Authors: Li, Ao, Liu, Zongzhi, Lezon-Geyda, Kimberly, Sarkar, Sudipa, Lannin, Donald, Schulz, Vincent, Krop, Ian, Winer, Eric, Harris, Lyndsay, Tuck, David
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130254/
https://ncbi.nlm.nih.gov/pubmed/21398628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr014
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