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Thermal activation of the bovine Hsc70 molecular chaperone at physiological temperatures: physical evidence of a molecular thermometer

Defferential scanning calorimetry was used to monitor the thermal transitions of the 70 kDa heat shock cognate protein (Hsc70). Hsc70 had endothermic trasitions with midpoints (Tm) at 59°C and 63°C in the absence and presence of ATP, respectively, and a similar increase in Tm was observed using intr...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Leung, Sau-Mei, Senisterra, Guillermo, Ritchie, Kenneth P., Sadis, Seth E., Lepock, James R., Hightower, Lawrence E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cell Stress Society International 1996
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC313020/
https://ncbi.nlm.nih.gov/pubmed/9222592
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