Role of Excitatory Amino Acid Transporter-2 (EAAT2) and Glutamate in Neurodegeneration: Opportunities for Developing Novel Therapeutics

Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory amino acid transporter (EAAT)-2 is one of the major glutamate transporters expressed predominantly in astroglial cells and is responsible for 90% of total glutamate uptake. Glutamate transporters tightly reg...

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Main Authors: KIM, KEETAE, LEE, SEOK-GEUN, KEGELMAN, TIMOTHY P., SU, ZHAO-ZHONG, DAS, SWADESH K., DASH, RUPESH, DASGUPTA, SANTANU, BARRAL, PAOLA M., HEDVAT, MICHAEL, DIAZ, PAUL, REED, JOHN C., STEBBINS, JOHN L., PELLECCHIA, MAURIZIO, SARKAR, DEVANAND, FISHER, PAUL B.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130100/
https://ncbi.nlm.nih.gov/pubmed/21792905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22609
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