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Elevation of Intracellular Calcium in Clonal Neuronal and Embryonic Kidney Cells Involves Endogenous Endothelin-A Receptors Linked to Phospholipase C Through Gα(q/11)

Endothelin-1 (ET-1) is a pain mediator, elevated in skin after injury, which potentiates noxious thermal and mechanical stimuli (hyperalgesia) through the activation of ET(A) (and, perhaps, ET(B)) receptors on pain fibers. Part of the mechanism underlying this effect has recently been shown to invol...

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Detalhes bibliográficos
Main Authors: Montmayeur, Jean-Pierre, Barr, Travis P., Kam, Sarah A., Packer, Samuel J., Strichartz, Gary R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130094/
https://ncbi.nlm.nih.gov/pubmed/21515378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2011.04.003
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