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Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GNDF in astroglia

Amantadine is commonly given to alleviate L-DOPA-induced dyskinesia of Parkinson’s disease (PD) patients. Animal and human evidence showed that amantadine may also exert neuroprotection in several neurological disorders. Additionally, it is generally believed that this neuroprotection results from t...

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Detalhes bibliográficos
Main Authors: Ossola, Bernardino, Schendzielorz, Nadia, Chen, Shih-Heng, Bird, Gary S., Tuominen, Raimo K., Männistö, Pekka T., Hong, Jau-Shyong
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130082/
https://ncbi.nlm.nih.gov/pubmed/21586298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2011.04.030
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