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RTL551 Treatment of EAE Reduces CD226 and T-bet+ CD4 T Cells in Periphery and Prevents Infiltration of T-bet+ IL-17, IFN-γ Producing T Cells into CNS

Recombinant T cell receptor ligands (RTLs) that target encephalitogenic T-cells can reverse clinical and histological signs of EAE, and are currently in clinical trials for treatment of multiple sclerosis. To evaluate possible regulatory mechanisms, we tested effects of RTL therapy on expression of...

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Main Authors: Sinha, Sushmita, Miller, Lisa M., Subramanian, Sandhya, Burrows, Gregory G., Vandenbark, Arthur A., Offner, Halina
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130056/
https://ncbi.nlm.nih.gov/pubmed/21750737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021868
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