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RTL551 Treatment of EAE Reduces CD226 and T-bet+ CD4 T Cells in Periphery and Prevents Infiltration of T-bet+ IL-17, IFN-γ Producing T Cells into CNS

Recombinant T cell receptor ligands (RTLs) that target encephalitogenic T-cells can reverse clinical and histological signs of EAE, and are currently in clinical trials for treatment of multiple sclerosis. To evaluate possible regulatory mechanisms, we tested effects of RTL therapy on expression of...

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Bibliografiske detaljer
Main Authors: Sinha, Sushmita, Miller, Lisa M., Subramanian, Sandhya, Burrows, Gregory G., Vandenbark, Arthur A., Offner, Halina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130056/
https://ncbi.nlm.nih.gov/pubmed/21750737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021868
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