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RTL551 Treatment of EAE Reduces CD226 and T-bet+ CD4 T Cells in Periphery and Prevents Infiltration of T-bet+ IL-17, IFN-γ Producing T Cells into CNS

Recombinant T cell receptor ligands (RTLs) that target encephalitogenic T-cells can reverse clinical and histological signs of EAE, and are currently in clinical trials for treatment of multiple sclerosis. To evaluate possible regulatory mechanisms, we tested effects of RTL therapy on expression of...

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Autors principals: Sinha, Sushmita, Miller, Lisa M., Subramanian, Sandhya, Burrows, Gregory G., Vandenbark, Arthur A., Offner, Halina
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130056/
https://ncbi.nlm.nih.gov/pubmed/21750737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021868
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