Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis

Recombinant T cell ligands (RTLs) ameliorate experimental autoimmune encephalomyelitis (EAE) in antigen specific manner. We evaluated effects of RTL401 (I-A(s) α1β1 + PLP-139-151) on splenocytes from mice with EAE to study RTL- T cell-tolerance-inducing mechanisms. RTLs bound to B, macrophages and D...

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Autores principales: Sinha, Sushmita, Miller, Lisa, Subramanian, Sandhya, McCarty, Owen, Proctor, Thomas, Meza-Romero, Roberto, Burrows, Gregory G., Vandenbark, Arthur A., Offner, Halina
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924959/
https://ncbi.nlm.nih.gov/pubmed/20546940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2010.04.013
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