Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats

Matrix metalloproteases (MMPs) are a family of zinc peptidases involved in extracellular matrix turnover. There is evidence that increased MMP activity is involved in remodeling of resistance vessels in chronic hypertension. Thus we hypothesized that inhibition of MMP activity with doxycycline (DOX)...

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Detaylı Bibliyografya
Asıl Yazarlar: Pires, Paulo W., Rogers, Curt T., McClain, Jonathon L., Garver, Hannah S., Fink, Gregory D., Dorrance, Anne M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2011
Konular:
Vascular Biology and Microcirculation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129920/
https://ncbi.nlm.nih.gov/pubmed/21551278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01206.2010
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