Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats

Matrix metalloproteases (MMPs) are a family of zinc peptidases involved in extracellular matrix turnover. There is evidence that increased MMP activity is involved in remodeling of resistance vessels in chronic hypertension. Thus we hypothesized that inhibition of MMP activity with doxycycline (DOX)...

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Detalhes bibliográficos
Main Authors: Pires, Paulo W., Rogers, Curt T., McClain, Jonathon L., Garver, Hannah S., Fink, Gregory D., Dorrance, Anne M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Vascular Biology and Microcirculation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129920/
https://ncbi.nlm.nih.gov/pubmed/21551278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01206.2010
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