mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON

The mammalian target of rapamycin (mTOR) signaling exists in two complexes: mTORC1 and mTORC2. Neurotensin (NT), an intestinal hormone secreted by enteroendocrine (N) cells in the small bowel, has important physiological effects in the gastrointestinal tract. The human endocrine cell line BON abunda...

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Detalhes bibliográficos
Main Authors: Li, Jing, Liu, Jianyu, Song, Jun, Wang, Xiaofu, Weiss, Heidi L., Townsend, Courtney M., Gao, Tianyan, Evers, B. Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Receptors and Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129828/
https://ncbi.nlm.nih.gov/pubmed/21508335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00067.2011
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