Use of Cassette Dosing in Sandwich-Cultured Rat and Human Hepatocytes to Identify Drugs that Inhibit Bile Acid Transport

Hepatocellular accumulation of bile acids due to inhibition of the canalicular bile salt export pump (BSEP/ABCB11) is one proposed mechanism of drug-induced liver injury (DILI). Some hepatotoxic compounds also are potent inhibitors of bile acid uptake by Na(+)-dependent taurocholate cotransporting p...

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Main Authors: Wolf, Kristina K., Vora, Sapana, Webster, Lindsey O., Generaux, Grant T., Polli, Joseph W., Brouwer, Kim L. R.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129609/
https://ncbi.nlm.nih.gov/pubmed/19706322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2009.08.009
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