Limited importance of the dominant-negative effect of TP53 missense mutations

BACKGROUND: Heterozygosity of TP53 missense mutations is related to the phenomenon of the dominant-negative effect (DNE). To estimate the importance of the DNE of TP53 mutations, we analysed the percentage of cancer cases showing a single heterozygous mutation of TP53 and searched for a cell line wi...

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Detalhes bibliográficos
Main Authors: Stoczynska-Fidelus, Ewelina, Szybka, Malgorzata, Piaskowski, Sylwester, Bienkowski, Michal, Hulas-Bigoszewska, Krystyna, Banaszczyk, Mateusz, Zawlik, Izabela, Jesionek-Kupnicka, Dorota, Kordek, Radzislaw, Liberski, Pawel P, Rieske, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129589/
https://ncbi.nlm.nih.gov/pubmed/21668955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-243
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