Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs

We report long-term results from a large animal model of in vivo selection. Nine years ago, we transplanted two dogs (E900 and E958) with autologous marrow CD34(+) cells that had been transduced with a gammaretrovirus vector encoding a conditionally activatable derivative of the thrombopoietin recep...

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Detalhes bibliográficos
Main Authors: Okazuka, Kiyoshi, Beard, Brian C, Emery, David W, Schwarzwaelder, Kerstin, Spector, Michele R, Sale, George E, von Kalle, Christof, Kiem, Hans-Peter, Blau, C Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129573/
https://ncbi.nlm.nih.gov/pubmed/21326218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.8
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