Feasibility of Adenovirus-Mediated hNIS Gene Transfer and (131)I Radioiodine Therapy as a Definitive Treatment for Localized Prostate Cancer

We have developed a replication-competent adenovirus (Ad5-yCD/mutTK(SR39)rep-hNIS) armed with two suicide genes and the human sodium iodide symporter (hNIS) gene. In this context, hNIS can be used as a reporter gene in conjunction with nuclear imaging and as a potentially therapeutic gene when combi...

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Detalhes bibliográficos
Main Authors: Barton, Kenneth N, Stricker, Hans, Elshaikh, Mohamed A, Pegg, Jan, Cheng, Jingfang, Zhang, Yingshu, Karvelis, Kastytis C, Lu, Mei, Movsas, Benjamin, Freytag, Svend O
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129572/
https://ncbi.nlm.nih.gov/pubmed/21587209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.89
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