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Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-α-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression

Liver injury accompanied by apoptosis of hepatocytes was provoked in mice by an intravenous injection of recombinant tumor necrosis factor-α (rTNF-α) (1.0 µg/kg) together with an intraperitoneal injection of D-galactosamine (D-gal) (500 mg/kg). Injection of various doses of dibutyryl cAMP (DBcAMP) p...

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Detalhes bibliográficos
Main Authors: Takano, Manabu, Arai, Toshiyuki, Mokuno, Yasuji, Nishimura, Hitoshi, Nimura, Yuji, Yoshikai, Yasunobu
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Stress Society International 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC312954/
https://ncbi.nlm.nih.gov/pubmed/9672246
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