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SIRT3 and Cancer: Tumor Promoter or Suppressor?

Sirtuins (SIRT1 7), the mammalian homologues of the Sir2 gene in yeast, have emerging roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and cancer. However, the role of several sirtuin family members, including SIRT1 and SIRT3, in cancer has been controversial. The aim o...

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Bibliographic Details
Main Authors: Alhazzazi, Turki Y., Kamarajan, Pachiyappan, Verdin, Eric, Kapila, Yvonne L.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129516/
https://ncbi.nlm.nih.gov/pubmed/21586315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbcan.2011.04.004
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