A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells

BACKGROUND: The survival rate of patients with head and neck squamous cell carcinoma (HNSCC) stands at approximately 50% and this has not improved in decades. This study developed a novel sirtuin-3 (SIRT3) inhibitor (LC-0296) and examined its role in altering HNSCC tumorigenesis. MATERIALS AND METHO...

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Udgivet i:Anticancer Res
Main Authors: ALHAZZAZI, TURKI Y., KAMARAJAN, PACHIYAPPAN, XU, YANLI, AI, TENG, CHEN, LIQIANG, VERDIN, ERIC, KAPILA, YVONNE L.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417072/
https://ncbi.nlm.nih.gov/pubmed/26722027
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