Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury is Influenced by Multiple HLA Class I and II Alleles

BACKGROUND & AIMS: Drug-induced liver injury (DILI), especially from antimicrobial agents, is an important cause of serious liver disease. Amoxicillin-clavulanate (AC) is a leading cause of idiosyncratic DILI, but little is understood about genetic susceptibility to this adverse reaction. METHOD...

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Autori principali: Lucena, M. Isabel, Molokhia, Mariam, Shen, Yufeng, Urban, Thomas J., Aithal, Guruprasad P., Andrade, Raúl J., Day, Christopher P., Ruiz-Cabello, Francisco, Donaldson, Peter T., Stephens, Camilla, Pirmohamed, Munir, Romero-Gomez, Manuel, Navarro, Jose Maria, Fontana, Robert J., Miller, Michael, Groome, Max, Bondon-Guitton, Emmanuelle, Conforti, Anita, Stricker, Bruno H. C., Carvajal, Alfonso, Ibanez, Luisa, Yue, Qun-Ying, Eichelbaum, Michel, Floratos, Aris, Pe’er, Itsik, Daly, Mark J., Goldstein, David B., Dillon, John F., Nelson, Matthew R., Watkins, Paul B., Daly, Ann K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129430/
https://ncbi.nlm.nih.gov/pubmed/21570397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.04.001
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