HER2 overexpression elicits a pro-inflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis

HER2 overexpression occurs in ~25% of breast cancers where it correlates with poor prognosis. Likewise, systemic inflammation in breast cancer correlates with poor prognosis although the process is not understood. In this study, we explored the relationship between HER2 and inflammation, comparing t...

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Hauptverfasser: Hartman, Zachary C., Yang, Xiao-Yi, Glass, Oliver, Lei, Gangjun, Osada, Takuya, Dave, Sandeep S., Morse, Michael A., Clay, Timothy M., Lyerly, Herbert Kim
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129398/
https://ncbi.nlm.nih.gov/pubmed/21518778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0308
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