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Analysis of mitosis and anti-mitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics

Cancer relies upon frequent or abnormal cell division but how the tumor microenvironment affects mitotic processes in vivo remains unclear, largely due to the technical challenges of optical access, spatial resolution, and motion. We developed high-resolution in vivo microscopy methods to visualize...

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Detalhes bibliográficos
Main Authors: Orth, J.D., Kohler, R.H., Foijer, F, Sorger, P.K., Weissleder, R., Mitchison, T.J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129392/
https://ncbi.nlm.nih.gov/pubmed/21712408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0412
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