miRNA and Vascular Cell Movement

miRNAs are a new class of endogenous small RNAs that negatively regulate gene expression at the posttranscriptional level. Accumulating experimental evidence shows that miRNAs regulate cellular apoptosis, proliferation, differentiation, and migration. Dysregulation of miRNA expression leads to vario...

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Autor principal: Yue, Junming
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129380/
https://ncbi.nlm.nih.gov/pubmed/21241758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2011.01.001
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spelling pubmed-31293802012-07-18 miRNA and Vascular Cell Movement Yue, Junming Adv Drug Deliv Rev Article miRNAs are a new class of endogenous small RNAs that negatively regulate gene expression at the posttranscriptional level. Accumulating experimental evidence shows that miRNAs regulate cellular apoptosis, proliferation, differentiation, and migration. Dysregulation of miRNA expression leads to various human diseases including cancer and cardiovascular disease. miRNA maturation is regulated at multiple steps by different mechanisms, including miRNA editing, hairpin loop binding, self-regulation, and cross-talk with other signaling pathways. Vascular cell movement plays a pivotal role in the development of various cancers and cardiovascular diseases. miRNAs have been found to regulate vascular cell movement. Presently the chemically synthesized antagomir, miRNA mimics have been widely used in investigating the biological functions of miRNA genes. The viral vectors, including adenoviral, lentiviral, and adeno-associated viral vectors, have been used to efficiently overexpress or knockdown miRNAs in vitro and in vivo. Therefore, targeting vascular cell movement using miRNA-based drug or gene therapy would provide a novel therapeutic approach in the treatment of cancers and vascular diseases. 2011-01-15 2011-07-18 /pmc/articles/PMC3129380/ /pubmed/21241758 http://dx.doi.org/10.1016/j.addr.2011.01.001 Text en
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
Yue, Junming
miRNA and Vascular Cell Movement
description miRNAs are a new class of endogenous small RNAs that negatively regulate gene expression at the posttranscriptional level. Accumulating experimental evidence shows that miRNAs regulate cellular apoptosis, proliferation, differentiation, and migration. Dysregulation of miRNA expression leads to various human diseases including cancer and cardiovascular disease. miRNA maturation is regulated at multiple steps by different mechanisms, including miRNA editing, hairpin loop binding, self-regulation, and cross-talk with other signaling pathways. Vascular cell movement plays a pivotal role in the development of various cancers and cardiovascular diseases. miRNAs have been found to regulate vascular cell movement. Presently the chemically synthesized antagomir, miRNA mimics have been widely used in investigating the biological functions of miRNA genes. The viral vectors, including adenoviral, lentiviral, and adeno-associated viral vectors, have been used to efficiently overexpress or knockdown miRNAs in vitro and in vivo. Therefore, targeting vascular cell movement using miRNA-based drug or gene therapy would provide a novel therapeutic approach in the treatment of cancers and vascular diseases.
author Yue, Junming
author_facet Yue, Junming
author_sort Yue, Junming
title miRNA and Vascular Cell Movement
title_short miRNA and Vascular Cell Movement
title_full miRNA and Vascular Cell Movement
title_fullStr miRNA and Vascular Cell Movement
title_full_unstemmed miRNA and Vascular Cell Movement
title_sort mirna and vascular cell movement
publishDate 2011
url https://ncbi.nlm.nih.gov/pmc/articles/PMC3129380/
https://ncbi.nlm.nih.gov/pubmed/21241758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2011.01.001
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