Adenosine Induces Loss of Actin Stress Fibers and Inhibits Contraction in Hepatic Stellate Cells via Rho Inhibition

The Rho/ROCK pathway is activated in differentiated hepatic stellate cells (HSCs) and is necessary for assembly of actin stress fibers, contractility, and chemotaxis. Despite the importance of this pathway in HSC biology, physiological inhibitors of the Rho/ROCK pathway in HSCs are not known. We dem...

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Autores principales: Sohail, Muhammad A., Hashmi, Ardeshir Z., Hakim, Wyel, Watanabe, Azuma, Zipprich, Alexander, Groszmann, Roberto J., Dranoff, Jonathan A., Torok, Natalie J., Mehal, Wajahat Z.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129263/
https://ncbi.nlm.nih.gov/pubmed/18844235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22589
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