Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants

Genome-wide association (GWA) studies have identified hundreds of common (minor allele frequency ≥5%) single nucleotide polymorphisms (SNPs) associated with phenotype traits or diseases, yet causal variants accounting for the association signals have rarely been determined. A question then raised is...

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Bibliographic Details
Main Authors: Takeuchi, Fumihiko, Kobayashi, Shotai, Ogihara, Toshio, Fujioka, Akihiro, Kato, Norihiro
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2011
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Method
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129254/
https://ncbi.nlm.nih.gov/pubmed/21441355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.115832.110
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