Enhanced Biosynthesis of Coagulation Factor VIII through Diminished Engagement of the Unfolded Protein Response

Human and porcine coagulation factor VIII (fVIII) display a biosynthetic efficiency differential that is being exploited for the development of new protein and gene transfer-based therapies for hemophilia A. The cellular and/or molecular mechanism(s) responsible for this phenomenon have yet to be un...

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Bibliographic Details
Main Authors: Brown, Harrison C., Gangadharan, Bagirath, Doering, Christopher B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129224/
https://ncbi.nlm.nih.gov/pubmed/21606503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238758
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