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Potent Family-18 Chitinase Inhibitors: X-RAY STRUCTURES, AFFINITIES, AND BINDING MECHANISMS
Six novel inhibitors of Vibrio harveyi chitinase A (VhChiA), a family-18 chitinase homolog, were identified by in vitro screening of a library of pharmacologically active compounds. Unlike the previously identified inhibitors that mimicked the reaction intermediates, crystallographic evidence from 1...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3129211/ https://ncbi.nlm.nih.gov/pubmed/21531720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.183376 |
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