Structural Flexibility of the Macrophage Dengue Virus Receptor CLEC5A: IMPLICATIONS FOR LIGAND BINDING AND SIGNALING

The human C-type lectin-like molecule CLEC5A is a critical macrophage receptor for dengue virus. The binding of dengue virus to CLEC5A triggers signaling through the associated adapter molecule DAP12, stimulating proinflammatory cytokine release. We have crystallized an informative ensemble of CLEC5...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Watson, Aleksandra A., Lebedev, Andrey A., Hall, Benjamin A., Fenton-May, Angharad E., Vagin, Alexei A., Dejnirattisai, Wanwisa, Felce, James, Mongkolsapaya, Juthathip, Palma, Angelina S., Liu, Yan, Feizi, Ten, Screaton, Gavin R., Murshudov, Garib N., O'Callaghan, Christopher A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129202/
https://ncbi.nlm.nih.gov/pubmed/21566123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226142
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi