Structural Flexibility of the Macrophage Dengue Virus Receptor CLEC5A: IMPLICATIONS FOR LIGAND BINDING AND SIGNALING

The human C-type lectin-like molecule CLEC5A is a critical macrophage receptor for dengue virus. The binding of dengue virus to CLEC5A triggers signaling through the associated adapter molecule DAP12, stimulating proinflammatory cytokine release. We have crystallized an informative ensemble of CLEC5...

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Detalhes bibliográficos
Main Authors: Watson, Aleksandra A., Lebedev, Andrey A., Hall, Benjamin A., Fenton-May, Angharad E., Vagin, Alexei A., Dejnirattisai, Wanwisa, Felce, James, Mongkolsapaya, Juthathip, Palma, Angelina S., Liu, Yan, Feizi, Ten, Screaton, Gavin R., Murshudov, Garib N., O'Callaghan, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129202/
https://ncbi.nlm.nih.gov/pubmed/21566123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226142
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