Molecular Insight into How HIV-1 Vpr Protein Impairs Cell Growth through Two Genetically Distinct Pathways

Vpr, a small HIV auxiliary protein, hijacks the CUL4 ubiquitin ligase through DCAF1 to inactivate an unknown cellular target, leading to cell cycle arrest at the G(2) phase and cell death. Here we first sought to delineate the Vpr determinants involved in the binding to DCAF1 and to the target. On t...

詳細記述

保存先:
書誌詳細
主要な著者: Maudet, Claire, Bertrand, Matthieu, Le Rouzic, Erwann, Lahouassa, Hichem, Ayinde, Diana, Nisole, Sébastien, Goujon, Caroline, Cimarelli, Andrea, Margottin-Goguet, Florence, Transy, Catherine
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
Cell Biology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129155/
https://ncbi.nlm.nih.gov/pubmed/21566118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.220780
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