Molecular Insight into How HIV-1 Vpr Protein Impairs Cell Growth through Two Genetically Distinct Pathways

Vpr, a small HIV auxiliary protein, hijacks the CUL4 ubiquitin ligase through DCAF1 to inactivate an unknown cellular target, leading to cell cycle arrest at the G(2) phase and cell death. Here we first sought to delineate the Vpr determinants involved in the binding to DCAF1 and to the target. On t...

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Hlavní autoři: Maudet, Claire, Bertrand, Matthieu, Le Rouzic, Erwann, Lahouassa, Hichem, Ayinde, Diana, Nisole, Sébastien, Goujon, Caroline, Cimarelli, Andrea, Margottin-Goguet, Florence, Transy, Catherine
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129155/
https://ncbi.nlm.nih.gov/pubmed/21566118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.220780
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