A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance

To identify key connections between DNA-damage repair and checkpoint pathways, we performed RNA interference screens for regulators of the ionizing radiation-induced G2 checkpoint, and we identified the breast cancer gene BRCA2. The checkpoint was also abrogated following depletion of PALB2, an inte...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Menzel, Tobias, Nähse-Kumpf, Viola, Kousholt, Arne Nedergaard, Klein, Ditte Kjærsgaard, Lund-Andersen, Christin, Lees, Michael, Johansen, Jens Vilstrup, Syljuåsen, Randi G, Sørensen, Claus Storgaard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
Soggetti:
Scientific Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128973/
https://ncbi.nlm.nih.gov/pubmed/21637299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.99
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi