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Continual Reassessment and Related Dose-Finding Designs
During the last twenty years there have been considerable methodological developments in the design and analysis of Phase 1, Phase 2 and Phase 1/2 dose-finding studies. Many of these developments are related to the continual reassessment method (CRM), first introduced by O’Quigley, Pepe and Fisher (...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3128794/ https://ncbi.nlm.nih.gov/pubmed/21731191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1214/10-STS332 |
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