NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease

BACKGROUND: Without appropriate cellular models the etiology of idiopathic Parkinson's disease remains unknown. We recently reported a novel patient-derived cellular model generated from biopsies of the olfactory mucosa (termed olfactory neurosphere-derived (hONS) cells) which express functiona...

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Main Authors: Cook, Anthony L., Vitale, Alejandra M., Ravishankar, Sugandha, Matigian, Nicholas, Sutherland, Greg T., Shan, Jiangou, Sutharsan, Ratneswary, Perry, Chris, Silburn, Peter A., Mellick, George D., Whitelaw, Murray L., Wells, Christine A., Mackay-Sim, Alan, Wood, Stephen A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128624/
https://ncbi.nlm.nih.gov/pubmed/21747966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021907
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