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2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer's Disease

Previously, we demonstrated that mitochondrial bioenergetic deficits preceded Alzheimer's disease (AD) pathology in the female triple-transgenic AD (3xTgAD) mouse model. In parallel, 3xTgAD mice exhibited elevated expression of ketogenic markers, indicating a compensatory mechanism for energy p...

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Detalhes bibliográficos
Main Authors: Yao, Jia, Chen, Shuhua, Mao, Zisu, Cadenas, Enrique, Brinton, Roberta Diaz
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128612/
https://ncbi.nlm.nih.gov/pubmed/21747957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021788
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