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Oxidation and Loss of Heme in Soluble Guanylyl Cyclase from Manduca Sexta
Oxidation and loss of heme in soluble guanylyl/guanylate cyclase (sGC), the nitric oxide receptor, is thought to be a major contributor to cardiovascular disease and is the target of compounds BAY 58-2667 and HMR1766. Using spectroelectrochemical titration, we found a truncated sGC to be highly stab...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3128461/ https://ncbi.nlm.nih.gov/pubmed/21639146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200794c |
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