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NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the Ligase IV pathway
In the yeast Saccharomyces cerevisiae, DNA double strand break (DSB) repair by nonhomologous end-joining (NHEJ) requires the DNA end-binding heterodimer Yku70p–Yku80p and the ligase Dnl4p associated with its cofactor Lif1p. NHEJ efficiency is down-regulated in MATa/MATα cells relative to MATa or MAT...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2001
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC312823/ https://ncbi.nlm.nih.gov/pubmed/11711435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.206801 |
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