Alloreactive and leukemia-reactive T cells are preferentially derived from naïve precursors in healthy donors: implications for immunotherapy with memory T cells

BACKGROUND: HLA mismatch antigens are major targets of alloreactive T cells in HLA-incompatible stem-cell transplantation, which can trigger severe graft-versus-host disease and reduce survival in transplant recipients. Our objective was to identify T-cell subsets with reduced in vitro reactivity to...

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Detalhes bibliográficos
Main Authors: Distler, Eva, Bloetz, Andrea, Albrecht, Jana, Asdufan, Saliha, Hohberger, Alexander, Frey, Michaela, Schnürer, Elke, Thomas, Simone, Theobald, Matthias, Hartwig, Udo F., Herr, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128222/
https://ncbi.nlm.nih.gov/pubmed/21486863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.037481
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