Hierarchical phosphorylation of the translation inhibitor 4E-BP1

In most instances, translation is regulated at the initiation phase, when a ribosome is recruited to the 5′ end of an mRNA. The eIF4E-binding proteins (4E-BPs) interdict translation initiation by binding to the translation factor eIF4E, and preventing recruitment of the translation machinery to mRNA...

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Detalhes bibliográficos
Main Authors: Gingras, Anne-Claude, Raught, Brian, Gygi, Steven P., Niedzwiecka, Anna, Miron, Mathieu, Burley, Stephen K., Polakiewicz, Roberto D., Wyslouch-Cieszynska, Aleksandra, Aebersold, Ruedi, Sonenberg, Nahum
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2001
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC312813/
https://ncbi.nlm.nih.gov/pubmed/11691836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.912401
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