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Aggregation of γ-crystallins associated with human cataracts via domain swapping at the C-terminal β-strands
The prevalent eye disease age-onset cataract is associated with aggregation of human γD-crystallins, one of the longest-lived proteins. Identification of the γ-crystallin precursors to aggregates is crucial for developing strategies to prevent and reverse cataract. Our microseconds of atomistic mole...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3127930/ https://ncbi.nlm.nih.gov/pubmed/21670251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019152108 |
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