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Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways

Signaling pathways essential for axon regeneration, but not for neuron development or function, are particularly well suited targets for therapeutic intervention. We find that the parallel PMK-3(p38) and KGB-1(JNK) MAPK pathways must be coordinately activated to promote axon regeneration. Axon regen...

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Autors principals: Nix, Paola, Hisamoto, Naoki, Matsumoto, Kunihiro, Bastiani, Michael
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127873/
https://ncbi.nlm.nih.gov/pubmed/21670305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104830108
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