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Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex

The specificity of ubiquitin-mediated protein degradation with regards to the selection of substrates to be polyubiquitinated has only been determined rather recently. Substrate targeting by the N-end rule and HECT (homology to E6AP carboxyl terminus) domain ubiquitin ligases occurs through substrat...

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Autori principali: Pfleger, Cathie M., Lee, Ethan, Kirschner, Marc W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC312782/
https://ncbi.nlm.nih.gov/pubmed/11562349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.918201
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