An evolutionarily ‘young’ lysine residue in histone H3 attenuates transcriptional output in Saccharomyces cerevisiae

The DNA entry and exit points on the nucleosome core regulate the initial invasion of the nucleosome by factors requiring access to the underlying DNA. Here we describe in vivo consequences of eliminating a single protein–DNA interaction at this position through mutagenesis of histone H3 Lys 42 to a...

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Detalles Bibliográficos
Main Authors: Hyland, Edel M., Molina, Henrik, Poorey, Kunal, Jie, Chunfa, Xie, Zhi, Dai, Junbiao, Qian, Jiang, Bekiranov, Stefan, Auble, David T., Pandey, Akhilesh, Boeke, Jef D.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2011
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127431/
https://ncbi.nlm.nih.gov/pubmed/21685365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2050311
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