Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein

PML-RARα oncoprotein is a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-α (RARα) and causes acute promyelocytic leukemias (APL). A hallmark of all-trans retinoic acid (ATRA) responses in APL is PML-RARα degradation, which promotes cell differentiation. Here, we demons...

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Bibliographic Details
Main Authors: Wang, Zhuo, Cao, Lizhi, Kang, Rui, Yang, Minghua, Liu, Liying, Zhao, Yiming, Yu, Yan, Xie, Min, Yin, Xiaocheng, Livesey, Kristen M, Tang, Daolin
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2011
Subjects:
Basic Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127220/
https://ncbi.nlm.nih.gov/pubmed/21187718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.4.14397
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